Tert-butyl 3,5-dimethylpiperazine-1-carboxylate → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-3,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[C:16]([O:20][C:21]([N:23]1[CH2:28][CH:27]([CH3:29])[NH:26][CH:25]([CH3:30])[CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[CH2:28][CH:27]([CH3:29])[N:26]([CH2:11][C:10]2[CH:13]=[CH:14][CH:15]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH:25]([CH3:30])[CH2:24]1)=[O:22])([CH3:19])([CH3:17])[CH3:18]Participants
3
Procedure
Intermediate 1 was coupled with 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 417.
Sources & evidence
- ORD record
- ord-8229c519091c4ae290ba05c9944350cd
- Source dataset
- uspto-grants-2012_09