Hydrogen Sulfide → 4-Pyridineethanethioamide
Reaction equation
[SH2:1].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1>CO>[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[S:1])[NH2:10])=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
Hydrogen sulfide was passed through a solution of 2-(pyridin-4-yl)acetonitrile (2.5 g) in 30% strength ammoniacal methanol (12 ml) at 0° C. for 30 minutes. The resulting reaction mixture was stirred at 25° C. for 16 hours. The solid which had precipitated was filtered out, washed with ether and dried. The desired product was obtained in a yield of 76%.
Workup
- customThe resulting reaction mixture
- customThe solid which had precipitated
- filtrationwas filtered out
- washwashed with ether
- customdried
Sources & evidence
- ORD record
- ord-eded4053db374855904b29a20391c05a
- Source dataset
- uspto-grants-2012_09
- Patent number
- US08268814B2
Reaction notes
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