Ethylamine → N-[4-(1-Aminoethyl)-2-methoxyphenyl]methanesulfonamide

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]([NH:16]C(=O)OCC2C=CC=CC=2)[CH3:15])[CH:6]=[CH:7][C:8]=1[NH:9][S:10]([CH3:13])(=[O:12])=[O:11].C(N)C>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]([NH2:16])[CH3:15])[CH:6]=[CH:7][C:8]=1[NH:9][S:10]([CH3:13])(=[O:12])=[O:11]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 69528574HCID 69528574, compound

Product 1

HCID 69528201N-[4-(1-Aminoethyl)-2-methoxyphenyl]methanesulfonamide

Procedure

Through similar procedure to that in Example 1-2 excepting using Benzyl N-{1-[3-methoxy-4-(methylsulfonylamino)phenyl]ethyl}carbamate (14-1) as a starting material, □1□3-Methoxy-4-(methylsulfonylamino)phenyl]ethyl amine (14-3, CHK-570) having following physicochemical properties was synthesized:

Workup

customwas synthesized

Sources & evidence

ORD record: ord-8d2a44d3740347898bf963d84966a48b
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08642657B2

Reaction notes

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