HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239Generated: October 23, 2026
Morpholine → Ethyl 5-morpholin-4-ylpyridine-3-carboxylate
https://huagongshe.com/en/reaction/239
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Ethyl 5-bromopyridine-3-carboxylate | HCID 140785 | — |
| Reagent | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl | HCID 2734217 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl 5-morpholin-4-ylpyridine-3-carboxylate | HCID 71565412 | 0% |
Reaction Steps
ethyl 5-bromonicotinate (200 mg, 0.87 mmol), morpholine (0.083 mL, 0.96 mmol), sodium 2-methylpropan-2-olate (167 mg, 1.74 mmol) and 2'-(dicyclohexylphosphino)-N,N-dimethylbiphenyl-2-amine (17.11 mg, 0.04 mmol) were suspended in dioxane (5 mL). The reaction flask was purged with nitrogen and TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) (19.90 mg, 0.02 mmol) was added. The reaction was stirred at 80 °C for 90 minutes. LCMS analysis appeared to indicate addition of 2 morpholine rings and the reaction was abandoned.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-bddc6734b7ce4143a8ed8f8385933b6e |
|---|
| Source note | 750 AstraZeneca ELN dataset |
|---|
