Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → Tert-butyl(4-cyano-2-ethynylphenoxy)acetate
Reaction equation
C(OC(=O)COC1C=CC(Cl)=CC=1C#C)(C)(C)C.[C:19]([O:23][C:24](=[O:41])[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][C:28]=1[C:35]#[C:36][Si](C)(C)C)([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24](=[O:41])[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][C:28]=1[C:35]#[CH:36])([CH3:22])([CH3:21])[CH3:20]Participants
3
Procedure
Following the general method as outlined in Intermediate 3, starting from tert-butyl{4-cyano-2-[(trimethylsilyl)ethynyl]phenoxy}acetate (Intermediate 45), the title compound was obtained as an oil in 72% yield.
Sources & evidence
- ORD record
- ord-5865ed61d9e3490ea8438efdd672659c
- Source dataset
- uspto-grants-2012_09
- DOI