Dimethylamine → 3-bromo-N,N-dimethylbenzamide

HRID 2390238Notes

Reaction equation

Br[C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]2[CH2:13]COC[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[Br:16]C1C=C(C=CC=1)C(Cl)=O.CNC>>[Br:16][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:2]=1)[C:6]([N:8]([CH3:13])[CH3:9])=[O:7]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 74377Benzoyl chloride, 3-bromo-

HCID 5321484-(4-Bromobenzoyl)morpholine

Product 1

HCID 33358263-bromo-N,N-dimethylbenzamideYield 85%

Procedure

Following the general method as outlined in Intermediate 174, starting from 3-bromobenzoyl chloride and dimethylamine, the title compound was obtained as a orange sticky solid in 85% yield.

Sources & evidence

ORD record: ord-45cbbc15817f4d2185f7d882de003a09
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08273769B2

Reaction notes

Loading…