Thiourea → 4,5,6,7-Tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine dihydrobromide
Reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[BrH:5].[Br:6][CH:7]1[C:12](=O)[CH2:11][CH2:10][NH:9][CH2:8]1>C(O)C>[BrH:6].[BrH:5].[N:1]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[S:3][C:2]=1[NH2:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4.55 g thiourea was added to 15.2 g 3-Bromo-piperidin-4-one hydrobromide in 152 mL ethanol and refluxed for 20 h. The reaction was cooled and the solid was filtered, washed with ethanol and dried to give 15.8 g of the desired product., (M+H)+: 184
Workup
- temperaturerefluxed for 20 h
- temperatureThe reaction was cooled
- filtrationthe solid was filtered
- washwashed with ethanol
- customdried
Sources & evidence
- ORD record
- ord-82ccc37c36934afb9a5db2670d12ed21
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08642774B2
Reaction notes
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