Formic Acid → HCID 21683295, compound
Reaction equation
Cl.Cl.[CH3:3][O:4][C:5]1[N:10]=[C:9]([NH2:11])[C:8]([NH2:12])=[CH:7][CH:6]=1.[CH:13](O)=O>>[CH3:3][O:4][C:5]1[N:10]=[C:9]2[N:11]=[CH:13][NH:12][C:8]2=[CH:7][CH:6]=1Participants
3
Procedure
10.19 g of 6-methoxypyridine-2,3-diamine dihydrochloride were dissolved in 100 ml formic acid and stirred under reflux for 72 h. The formic acid was evaporated under vacuum and the residue was dried under vacuum at 95° C. to give crude 5-methoxy-1H-imidazo[4,5-b]pyridine (as hydrochloride and/or as formic acid salt and/or as free base) that was used for the following step without further purification.
Workup
- temperatureunder reflux for 72 h
- customThe formic acid was evaporated under vacuum
- customthe residue was dried under vacuum at 95° C.
Sources & evidence
- ORD record
- ord-861b197e53da4238a76a9264b8651928
- Source dataset
- uspto-grants-2012_09
- Patent number
- US08273890B2
Reaction notes
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