Water → 2-Bromo-5,6-dimethoxy-3-nitropyridine
Reaction equation
Br[C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([N+:10]([O-:12])=[O:11])=[C:4]([Br:13])[N:3]=1.[CH3:14][O-:15].[Na+].O>CO>[Br:13][C:4]1[C:5]([N+:10]([O-:12])=[O:11])=[CH:6][C:7]([O:8][CH3:9])=[C:2]([O:15][CH3:14])[N:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
20 g of 2,6-dibromo-3-methoxy-5-nitropyridine (example E3) were dissolved in 550 ml of anhydrous methanol at 30-40° C. 4.6 g sodium methoxide dissolved in 30 ml anhydrous methanol were added to this solution. The reaction mixture was stirred for one hour at room temperature, poured into 700 ml of water and stored in the refrigerator overnight. The precipitate was filtered, washed with ice cold water and dried under vacuum to yield the title compound.
Workup
- additionwere added to this solution
- customstored in the refrigerator overnight
- filtrationThe precipitate was filtered
- washwashed with ice cold water
- customdried under vacuum
Sources & evidence
- ORD record
- ord-b8291901f19049abb7a7146e154e55df
- Source dataset
- uspto-grants-2012_09
- Patent number
- US08273890B2
Reaction notes
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