Dichloromethane methanol → 8-(2-Chloro-5-methoxy-phenyl)-Quinoxaline-5-carboxylic acid (1H-imidazol-2-yl)amide

HRID 2391808

Reaction equation

C(N1CCN(C2C=[C:11]([NH:15][C:16]([C:18]3[C:19]4[N:20]=[CH:21][CH:22]=[N:23][C:24]=4[C:25]([C:28]4[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30]C=4Cl)=[CH:26][CH:27]=3)=[O:17])C=CC=2)CC1)C.[CH2:37]([Cl:39])Cl.CO>>[NH:20]1[CH:19]=[CH:24][N:23]=[C:11]1[NH:15][C:16]([C:18]1[C:19]2[N:20]=[CH:21][CH:22]=[N:23][C:24]=2[C:25]([C:28]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:37]=2[Cl:39])=[CH:26][CH:27]=1)=[O:17]

Participants

Reactant 2

HCID 21226129Dichloromethane methanol

HCID 445159808-(2-Chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Product 1

HCID 445162818-(2-Chloro-5-methoxy-phenyl)-Quinoxaline-5-carboxylic acid (1H-imidazol-2-yl)amide

Procedure

The title compound was prepared in analogy to the procedures described in Example 14 but using 8-(2-chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid (Example 63) in Step 14.1. Title compound: ESI-MS: 380.0 [M+H]+; tR=3.61 min (System 1); TLC: Rf=0.36 (DCM/MeOH, 95:5).

Workup

customThe title compound was prepared in analogy to the procedures

Sources & evidence

ORD record: ord-58eea5b410ec46c58651e3ddd6c232f9
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08273882B2

Linked notes

Loading…