1-(4-Nitrophenyl)-1H-1,2,4-triazole → 4-(1,2,4-Triazol-1-yl)aniline
Reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1>C(O)C.[Pd]>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
4-(1,2,4-Triazol-1-yl)nitrobenzene (0.5 g, 3 mmol) and Pd/C (500 mg) in ethanol (50 ml) were hydrogenated at rtp for 3 days. The suspension was filtered through celite, evaporated under reduced pressure to afford a white solid (418 mg, 87%).
Workup
- filtrationThe suspension was filtered through celite
- customevaporated under reduced pressure
Sources & evidence
- ORD record
- ord-464669df42a34bb8ac4435d69214ab86
- Source dataset
- uspto-grants-1998_09
- Patent number
- US05801170
Reaction notes
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