HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoate → N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoate | HCID 104541 | — |
| Reactant | 2-Acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid | HCID 18980788 | — |
| Product | N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester | HCID 10075398 | 78% |
Reaction Steps
Using the procedure described in Example 60, but starting with 2-acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid and tyrosine benzyl ester, N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester is obtained in a 78% yield in the form of a white solid, having the following characteristics: Rf =0.16 [hexane/ethyl acetate (65:35 by volume)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05801274 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-a0498eba4daa4d7b8e491eda8464d61e |
| Source note | uspto-grants-1998_09 |