Acetic Anhydride → HCID 136381103, compound

HRID 2393653

Reaction equation

HRID 2393653 reaction equation
[NH2:1][C:2](=[N:20][N+:21]([O-:23])=[O:22])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:9]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)=[O:10])[NH2:8].[C:24](OC(=O)C)(=[O:26])[CH3:25]>C(O)(=O)C>[C:24]([NH:8][C@@H:7]([C:9]([NH:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=1)=[O:10])[CH2:6][CH2:5][CH2:4][NH:3][C:2]([NH2:1])=[N:20][N+:21]([O-:23])=[O:22])(=[O:26])[CH3:25]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 136381090(R)-N5-[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl)-ornithinamide

Product 1

HCID 136381103HCID 136381103, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

0.3 g (0.925 mMol) of (R)-N5 -[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-ornithinamide were dissolved in 3 ml of glacial acetic acid and after the addition of 3 ml (0.032 Mol) of acetic anhydride the mixture was heated to a reaction temperature of 50° C. for 30 minutes. The product remaining after the volatile components had evaporated off was further processed without purification.

Workup

  1. customhad evaporated off
  2. customwas further processed without purification

Sources & evidence

ORD record
ord-31ea9a0506fa40a8941c09e0e2b196c5
Source dataset
uspto-grants-1998_09
Patent number
US05807875

Linked notes

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