Acetic Anhydride → Methyl 1-acetyl-3-formylindole-6-carboxylate

HRID 23944

Reaction equation

HRID 23944 reaction equation

[CH:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=2)[NH:5][CH:4]=1)=[O:2].[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[C:8]([C:12]([O:14][CH3:15])=[O:13])[CH:7]=2)[C:3]([CH:1]=[O:2])=[CH:4]1)(=[O:18])[CH3:17]

Participants

3

Reactant 2

HCID 7918Acetic Anhydride

HCID 735867methyl 3-formyl-1H-indole-6-carboxylate

Product 1

HCID 22569996Methyl 1-acetyl-3-formylindole-6-carboxylate

Procedure

A suspension of methyl 3-formylindole-6-carboxylate (1 g, 4.93 mmol) in acetic anhydride (10 ml) was refluxed for 2 h.

Workup

temperaturewas refluxed for 2 h.

Sources & evidence

ORD record: ord-4bb8a028c46f4ed88d088328239de392
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06855715B1

Linked notes

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