Potassium Hydroxide → HCID 19418871, compound

Reaction equation

[Br:1][C:2]1[C:3]([O:15][CH3:16])=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([O:13]C)=[O:12])=[CH:7]2.[OH-].[K+]>>[Br:1][C:2]1[C:3]([O:15][CH3:16])=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([OH:13])=[O:12])=[CH:7]2

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 16726759Methyl 7-bromo-6-methoxy-1H-indole-2-carboxylate

Product 1

HCID 19418871HCID 19418871, compound

Procedure

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 7-bromo-6-methoxyindole carboxylate (PREPARATION 81, 0.36 g) and potassium hydroxide (0.11 g), the title compound is obtained, NMR (300 MHz, CD3OD), 7.58, 7.20, 6.96 and 3.93 δ.

Workup

customthe general procedure of PREPARATION 63

Sources & evidence

ORD record: ord-82efb92adb9a470ead805f5bf6fbd8f8
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05489593

Reaction notes

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