Formic Acid → N-benzyl-N-methylaminoethanol
Reaction equation
[CH2:1]([NH:8][CH:9]([OH:11])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:12](O)=O.C=O>CO>[CH2:1]([N:8]([CH:9]([OH:11])[CH3:10])[CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture consisting of 151 g (1 mol) of N-benzylaminoethanol, 120 ml of 90% formic acid, 120 ml of a 35% aqueous formaldehyde solution and 1 liter of methanol is heated under reflux for 20 hours. The solvent is evaporated off in vacuo and the residue is treated with an aqueous sodium hydroxide solution and then extracted with methylene chloride. After customary treatment, the product is purified by distillation. 138 g of the desired product are obtained.
Workup
- temperatureis heated
- temperatureunder reflux for 20 hours
- customThe solvent is evaporated off in vacuo
- additionthe residue is treated with an aqueous sodium hydroxide solution
- extractionextracted with methylene chloride
- distillationAfter customary treatment, the product is purified by distillation
Sources & evidence
- ORD record
- ord-7706dd13d1e5428485c94275185534d2
- Source dataset
- uspto-grants-1996_02
- Patent number
- US05492912
Reaction notes
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