1H-1,2,4-Triazole → HCID 57201892, compound

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[NH:15]1[CH:19]=[N:18][CH:17]=[N:16]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@H:12]([N:15]2[CH:19]=[N:18][CH:17]=[N:16]2)[CH3:13])[CH2:11][O:10]1

Participants

Reactant 2

HCID 92571H-1,2,4-Triazole

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol

Product 1

HCID 57201892HCID 57201892, compoundYield 56.5%

Procedure

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (1.17 g) and 1H-1,2,4-triazole (404 mg), (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-(1H-1,2,4-triazol-1-yl)ethyl]oxirane (830 mg) was obtained by the same way as in Reference Example 2.

Sources & evidence

ORD record: ord-6125b32a33044f0aa9ebe7057a9607ff
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05495024

Reaction notes

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