HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(2-Methylbenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Methylbenzoyl chloride | HCID 70276 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-[2-(2-Cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole | HCID 21313365 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-Methylbenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole | HCID 21313328 | — |
Reaction Steps
1-(2-Methylbenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole is prepared by reaction of 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole with sodium hydride in DMF and reaction of the resulting sodium salt with 2-methylbenzoyl chloride following the procedure described above in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04021431 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-d1b5b4ca11d542c18a2fbc24639e9f88 |
| Source note | uspto-grants-1977_05 |