Dicyclohexylcarbodiimide → 2-{[2-Aminoacetamido-5-chloro-alpha-(2-fluorophenyl)benzylidene]amino}ethanol

Participants

Reaction Steps

To a solution of 4.5g of N,N'-dicyclohexylcarbodiimide in 100ml of dimethylformamide is added a solution of 2.2g of glycine hydrochloride in 2.2ml of water in a period of about 30 seconds under stirring and ice-cooling. Immediately a solution of 3.2g of 2-{[2-amino-5-chloro-α-(2-fluorophenyl)benzylidene]amino}ethanol in 10ml of tetrahydrofuran is added dropwise to the above solution and the mixture is stirred for further 3 hours. After completion of the reaction, the reaction mixture is treated by the same manner as described in the Example 1, yielding 1.7g of the desired product melting at 128°-132° C.

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