Thionyl Chloride → 4-(2-Diethylaminoethoxy)benzoyl chloride hydrochloride
Reaction equation
[ClH:1].[CH2:2]([N:4]([CH2:17][CH3:18])[CH2:5][CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=1)[CH3:3].S(Cl)([Cl:21])=O>C(Cl)Cl>[ClH:21].[CH2:2]([N:4]([CH2:17][CH3:18])[CH2:5][CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([Cl:1])=[O:13])=[CH:10][CH:9]=1)[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-(2-Diethylaminoethoxy)benzoic acid hydrochloride is suspended in methylene chloride and a five-fold excess of thionyl chloride is added. The mixture is refluxed until the solid dissolves, then concentrated under reduced pressure to give 4-(2-diethylaminoethoxy)benzoyl chloride hydrochloride.
Workup
- temperatureThe mixture is refluxed until the solid
- dissolutiondissolves
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-ab3961a2faf44469b1ac94b0d17982ee
- Source dataset
- uspto-grants-1977_05
- Patent number
- US04024273
Reaction notes
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