Ethylamine → Ethyl 3-(ethylamino)-3-oxopropanoate
Reaction equation
[C:1]([CH2:6][C:7](Cl)=[O:8])([O:3][CH2:4][CH3:5])=[O:2].[CH2:10]([NH2:12])[CH3:11]>C1C=CC=CC=1>[CH2:10]([NH:12][C:7](=[O:8])[CH2:6][C:1]([O:3][CH2:4][CH3:5])=[O:2])[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 15.0 g. (0.1 mole) of carboethoxyacetyl chloride in 150 ml. of benzene is added, with cooling, 9.9 g. (0.22 mole) of ethylamine in 50 ml. of the same solvent. The reaction mixture is allowed to stir at room temperature overnight, followed by filtration. The filtrate is washed with water, dried over sodium sulfate and concentrated to dryness. The residual product is washed several times with diisopropyl ether and dried in vacuo. The crude product is employed in the next reaction without further purification.
Workup
- temperaturewith cooling
- filtrationfollowed by filtration
- washThe filtrate is washed with water
- dry with materialdried over sodium sulfate
- concentrationconcentrated to dryness
- washThe residual product is washed several times with diisopropyl ether
- customdried in vacuo
- customThe crude product is employed in the next reaction without further purification
Sources & evidence
- ORD record
- ord-4828fce972cb42fc92a4c50465ed5eea
- Source dataset
- uspto-grants-1977_05
- Patent number
- US04025504
Reaction notes
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