Ammonia → 10567-33-6
Reaction equation
[ClH:1].[C:2]([CH2:6][CH2:7][C:8](=[NH:11])OC)([O:4][CH3:5])=[O:3].[NH3:12]>CO>[ClH:1].[C:2]([CH2:6][CH2:7][C:8]([NH2:11])=[NH:12])([O:4][CH3:5])=[O:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension of 16.5 g. (0.09 mole) of methyl β-carbomethoxypropionimidate hydrochloride in 20 ml. of methanol at ice bath temperatures is added 12 ml. of the same solvent containing 1.7 g. of dissolved ammonia gas. The reaction mixture is allowed to stir at room temperature for 2 hrs., followed by filtration of some insoluble material and concentration of the filtrate to near dryness. The residual white solids are treated with ethanol, filtered and dried, 7.8 g. (51.5% yield), m.p. 132°-134° C.
Workup
- additionTo a suspension of 16.5 g
- additionof the same solvent containing 1.7 g
- filtration, followed by filtration of some insoluble material and concentration of the filtrate
- additionThe residual white solids are treated with ethanol
- filtrationfiltered
- customdried
Sources & evidence
- ORD record
- ord-19e1cc217e874d79b3d640ec2763b113
- Source dataset
- uspto-grants-1977_05
- Patent number
- US04025506
Reaction notes
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