1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine → 3-Ethylaminomethyl-3-hydroxypyrrolidine
Reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:14][NH:15][CH2:16][CH3:17])([OH:13])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:16]([NH:15][CH2:14][C:10]1([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:17]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
10 g (42.7 mmol) of 1-benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine in 60 ml of methanol are hydrogenated using 2 g of palladium/active carbon (10%) at 92°C. and 107 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
Workup
- customat 92°C.
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
Sources & evidence
- ORD record
- ord-77d18c2b5e734b77b792392d7ab8b6ef
- Source dataset
- uspto-grants-1995_09
- Patent number
- US05453422
Reaction notes
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