Ammonia → 2,5-Dichloropyrimidin-4-amine
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[CH:4][N:3]=1.[NH3:10]>CO>[Cl:1][C:2]1[N:7]=[C:6]([NH2:10])[C:5]([Cl:9])=[CH:4][N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2,4,5-trichloropyrimidine (2.2 ml) in 2M ammonia in methanol (50 ml) was stirred at room temperature overnight. The reaction was then concentrated in vacuo and the resultant solid was washed with water. The residue was triturated with methanol and the solid was isolated by vacuum filtration to furnish the title compound as a white solid (487 mg). 1H NMR (400 MHz, DMSO-d6): 8.18 (1H, s).
Workup
- concentrationThe reaction was then concentrated in vacuo
- washthe resultant solid was washed with water
- customThe residue was triturated with methanol
- customthe solid was isolated by vacuum filtration
Sources & evidence
- ORD record
- ord-2b20d8dd70124d54a83649e35e8bd5b6
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08796244B2
Reaction notes
Loading…