Reaction equation
[CH3:1][CH:2]1[CH2:6][O:5][C:4](=O)[CH2:3]1.S(Cl)([Cl:10])=O.[CH3:12][OH:13]>>[CH3:12][O:13][C:4](=[O:5])[CH2:3][CH:2]([CH3:1])[CH2:6][Cl:10]Participants
4
Conditions
- Temperature
- -10 °C
Procedure
4-Methyl-dihydro-furan-2-one (4 g, 39.95 mmol) was dissolved in MeOH (10 ml) and the solution was cooled to −10° C. Thionyl chloride (3.6 ml, 49.9 mmol) was added dropwise. The mixture was stirred at −10° C. for 2 hrs and hereafter for 16 hrs at room temperature. The mixture was concentrated in vacuo to give crude 4-Chloro-3-methyl-butyric acid methyl ester (4 g, 87%) which was used in the next step without further purification.
Workup
- concentrationThe mixture was concentrated in vacuo
Sources & evidence
- ORD record
- ord-d9a0411b42f941a58ad2f5a116be38e8
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08796262B2
Linked notes
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