4-Chloro-2-(trifluoromethyl)benzyl bromide → 1-[4-Chloro-2-(trifluoromethyl)benzyl]-3-iodo-1H-indazol-5-carbaldehyde
Reaction equation
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=[O:12])[CH:9]=2)[NH:4][N:3]=1.[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=1>>[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][N:4]2[C:5]3[C:10](=[CH:9][C:8]([CH:11]=[O:12])=[CH:7][CH:6]=3)[C:2]([I:1])=[N:3]2)=[C:16]([C:22]([F:23])([F:24])[F:25])[CH:15]=1Participants
3
Procedure
1-[4-Chloro-2-(trifluoromethyl)benzyl]-3-iodo-1H-indazol-5-carbaldehyde was prepared from 3-iodo-1H-indazol-5-carbaldehyde and 4-chloro-2-(trifluoromethyl)benzyl bromide following General Procedure A.
Sources & evidence
- ORD record
- ord-6df8e8a4d49b4e0481e01583150705eb
- Source dataset
- uspto-grants-2014_08