(Z)-4-amino-N-hydroxy-1,2,5-oxadiazole-3-carbonimidoyl chloride → HCID 178505103, compound

Reaction equation

Cl.[NH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([CH3:10])(=[O:9])=[O:8].[NH2:11][C:12]1[C:13]([C:17](Cl)=[N:18][OH:19])=[N:14][O:15][N:16]=1>>[NH2:11][C:12]1[C:13]([C:17](=[N:18][OH:19])[NH:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([CH3:10])(=[O:9])=[O:8])=[N:14][O:15][N:16]=1

Participants

Reactant 2

HCID 4040027(Z)-4-amino-N-hydroxy-1,2,5-oxadiazole-3-carbonimidoyl chloride

HCID 86638005N-(3-aminopropyl)methanesulfonamide hydrochloride

Product 1

HCID 178505103HCID 178505103, compoundYield 19%

Procedure

The desired compound was prepared according to the procedure of Example 17, step C, using N-(3-aminopropyl)methanesulfonamide hydrochloride and 4-amino-N-hydroxy-1,2,5-oxadiazole-3-carboximidoyl chloride [made according to Example 1, steps A through B] as the starting materials in 19% yield.

Sources & evidence

ORD record: ord-750bc09fc89d410487b8a6ddad0c44ac
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796319B2

Reaction notes

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