Methanol → 3-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile

HRID 240306

Reaction equation

HRID 240306 reaction equation
[O:1]=[C:2]1[C:14]2[C:9](=[N:10][C:11](C#N)=[C:12]([C:15]#[N:16])[N:13]=2)[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[CH3:19][OH:20]>>[CH3:19][O:20][C:11]1[N:10]=[C:9]2[C:8]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[C:2](=[O:1])[C:14]2=[N:13][C:12]=1[C:15]#[N:16]

Participants

3

Reactant 2

HCID 887MethanolHCID 2929299-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile

Product 1

HCID 160653533-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrileYield 126.5%

Procedure

To a suspension of 1 (1.10 g, 4.7 mmol) in MeOH (47 ml) sodium (110 mg) was added and the mixture was stirred at room temperature for 16 hours. The precipitate was filtered, washed with EtOH and dried under vacuum, yielding 3 (1.03 g, 93%) as yellow-green solid.

Workup

  1. additionwas added
  2. filtrationThe precipitate was filtered
  3. washwashed with EtOH
  4. customdried under vacuum

Sources & evidence

ORD record
ord-b40012b19977406f87d5a10b4b6e4989
Source dataset
uspto-grants-2014_02
Patent number
US08648076B2

Linked notes

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