Phenylmethyl 3-{3-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate → 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[3-(3-piperidinyl)propyl]-9H-purin-6-amine
Reaction equation
C(OC1N=C2C(N=C(OC)N2CCCC2CCCCN2)=C(N)N=1)CCC.[NH2:27][C:28]1[N:36]=[C:35]([O:37][C@@H:38]([CH3:42])[CH2:39][CH2:40][CH3:41])[N:34]=[C:33]2[C:29]=1[N:30]=[C:31]([O:62][CH3:63])[N:32]2[CH2:43][CH2:44][CH2:45][CH:46]1[CH2:51][CH2:50][CH2:49][N:48](C(OCC2C=CC=CC=2)=O)[CH2:47]1>>[CH3:42][C@H:38]([O:37][C:35]1[N:34]=[C:33]2[C:29]([N:30]=[C:31]([O:62][CH3:63])[N:32]2[CH2:43][CH2:44][CH2:45][CH:46]2[CH2:51][CH2:50][CH2:49][NH:48][CH2:47]2)=[C:28]([NH2:27])[N:36]=1)[CH2:39][CH2:40][CH3:41]Participants
3
Reactant 2
Product 1
Procedure
Prepared similarly to Intermediate 32 from phenylmethyl 3-{3-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate.