3,5-Dimethoxyaniline → 6-chloro-N-(3,5-dimethoxyphenyl)pyrazine-2-carboxamide
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8](Cl)=[O:9])[CH:5]=[N:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([O:20][CH3:21])[CH:19]=1)[NH2:16]>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:16][C:15]2[CH:17]=[C:18]([O:20][CH3:21])[CH:19]=[C:13]([O:12][CH3:11])[CH:14]=2)=[O:9])[CH:5]=[N:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The product from Example 15B was reacted with 3,5-dimethoxyaniline and TEA in CH2Cl2 as described in Example 15C to afford the title compound. MS (DCI/NH3) m/z 294 (M+H)+.
Sources & evidence
- ORD record
- ord-b54d3e8fccf04a6d8e5a22ec6e1bea0d
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648084B2
Reaction notes
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