3-(Propan-2-yloxy)aniline → 6-Chloro-N-(3-isopropoxyphenyl)pyrazine-2-carboxamide

HRID 240492Notes

Reaction equation

HRID 240492 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8](Cl)=[O:9])[CH:5]=[N:4][CH:3]=1.[CH:11]([O:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18])([CH3:13])[CH3:12]>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:18][C:17]2[CH:19]=[CH:20][CH:21]=[C:15]([O:14][CH:11]([CH3:13])[CH3:12])[CH:16]=2)=[O:9])[CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 5732203-(Propan-2-yloxy)anilineHCID 151496716-Chloropyrazine-2-carbonyl chloride

Product 1

HCID 848200206-Chloro-N-(3-isopropoxyphenyl)pyrazine-2-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 15B was reacted with 3-isopropoxyaniline and TEA in CH2Cl2 as described in Example 15C to afford the title compound. MS (DCI/NH3) m/z 309 (M+H)+.

Sources & evidence

ORD record
ord-034f9027d7134397ba6c3fe5d835148b
Source dataset
uspto-grants-2014_02
Patent number
US08648084B2

Reaction notes

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