Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole → (3aR,6aS)-tert-butyl 5-(5-(benzyloxy)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

HRID 240531

Reaction equation

HRID 240531 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[N:11][CH:12]=[C:13](Br)[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]1[C@@H:20]2[CH2:21][NH:22][CH2:23][C@@H:19]2[CH2:18][N:17]1[C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25]>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:22]2[CH2:21][C@@H:20]3[CH2:16][N:17]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:18][C@@H:19]3[CH2:23]2)[CH:12]=[N:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1514452Cis-2-boc-hexahydropyrrolo[3,4-C]pyrroleHCID 153891983-(Benzyloxy)-5-bromopyridine

Product 1

HCID 44190044(3aR,6aS)-tert-butyl 5-(5-(benzyloxy)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Procedure

3-(Benzyloxy)-5-bromopyridine and the product from Example 1C were processed as described in Example 53B to provide the title compound. MS (ESI) m/z 396 (M+H)+.

Sources & evidence

ORD record
ord-01df099ea86249c3b2138be726530fce
Source dataset
uspto-grants-2014_02
Patent number
US08648084B2

Linked notes

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