2-Amino-5-nitrobenzoic acid → HCID 178526470, compound
Reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.C(O)(=O)C.[CH:18](N)=[NH:19]>COC(O)C>[N+:11]([C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:18][N:19]=[C:4]2[OH:6])([O-:13])=[O:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 115 °C
Procedure
A mixture of 2-amino-5-nitrobenzoic acid (1000 g, 5 mol) and formamidine acetate (1000 g, 10 mol) were dissolved in methoxyethanol (4 L) and heated to 115° C. for 16 hours. After cooling the mixture to room temperature, ice water (5 L) was added and the mixture was stirred for 30 minutes before collecting the product (125 g, 14%) by filtration.
Workup
- temperatureAfter cooling the mixture to room temperature
- custombefore collecting the product (125 g, 14%)
- filtrationby filtration
Sources & evidence
- ORD record
- ord-c6eaa425e0df4e24ab878d970d8aa4c3
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648087B2
Reaction notes
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