Formamide → HCID 178518013, compound
Reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>O>[I:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:12][N:14]=[C:4]2[OH:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 190 °C
Procedure
A mixture of 2-amino-5-iodobenzoic acid (125 g, 475 mmol) and formamide (200 mL) was heated to 190° C. for 2 hours. After cooling to room temperature, the reaction mixture was poured into water (500 mL) and stirred for 2 hours. The solids were filtered and dried under high vacuum to provide the product (108 g, 83%).
Workup
- temperatureAfter cooling to room temperature
- filtrationThe solids were filtered
- customdried under high vacuum
Sources & evidence
- ORD record
- ord-1cf203d6a8f34d2ea4d9ba40e1884b22
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648087B2
Reaction notes
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