tert-Butyl pyrazolidine-1-carboxylate → HCID 71294447, compound

HRID 240685

Reaction equation

HRID 240685 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([OH:22])=O)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:23][C:24]([O:27][C:28]([N:30]1[CH2:34][CH2:33][CH2:32][NH:31]1)=[O:29])([CH3:26])[CH3:25]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([N:31]3[CH2:32][CH2:33][CH2:34][N:30]3[C:28]([O:27][C:24]([CH3:26])([CH3:25])[CH3:23])=[O:29])=[O:22])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:18])([F:19])[F:17])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21857793tert-Butyl pyrazolidine-1-carboxylateHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 71294447HCID 71294447, compound

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 1-pyrazolidinecarboxylic acid 1,1-dimethylethyl ester (CAN 57699-91-9) as starting materials; MS (EI) 486.2 (M+H)+.

Sources & evidence

ORD record
ord-13ad7180d565474e85d2285da3b37b3a
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Linked notes

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