N-Aminomorpholine → 5-cyclohexyl-N-morpholino-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240709

Reaction equation

HRID 240709 reaction equation
[CH:1]1([C:7]2[CH:8]=[C:9]([C:19](O)=[O:20])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:22]1([NH2:28])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[CH:1]1([C:7]2[CH:8]=[C:9]([C:19]([NH:28][N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[O:20])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:17])([F:18])[F:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712941235-cyclohexyl-N-morpholino-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 12c) and 4-morpholinamine (CAN 4319-49-7) as starting materials; LC-MS (UV peak area/ESI) 99.0%, 388.1849 (M+H)+.

Sources & evidence

ORD record
ord-123eee9cb1b34176b8e6448fbe480cf5
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Linked notes

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