1-Pyrrolidinamine → 5-cyclohexyl-N-(pyrrolidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240711

Reaction equation

HRID 240711 reaction equation
[CH:1]1([C:7]2[CH:8]=[C:9]([C:19]([OH:21])=O)[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:22]1([NH2:27])[CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:1]1([C:7]2[CH:8]=[C:9]([C:19]([NH:27][N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:21])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 279461-PyrrolidinamineHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712940015-cyclohexyl-N-(pyrrolidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 12c) and 1-pyrrolidinamine (CAN 16596-41-1) as starting materials; LC-MS (UV peak area/ESI) 100.0%, 372.1899 (M+H)+.

Sources & evidence

ORD record
ord-93b290fb7a964b32bda99af24fdc684c
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Linked notes

Loading…