3-Chloro-6-(1-methylhydrazinyl)pyridazine → N'-(6-chloropyridazin-3-yl)-5-cyclohexyl-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

HRID 240712

Reaction equation

HRID 240712 reaction equation
[CH:1]1([C:7]2[CH:8]=[C:9]([C:19]([OH:21])=O)[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:22][C:23]1[N:24]=[N:25][C:26]([N:29]([CH3:31])[NH2:30])=[CH:27][CH:28]=1>>[Cl:22][C:23]1[N:24]=[N:25][C:26]([N:29]([CH3:31])[NH:30][C:19]([C:9]2[CH:10]=[N:11][C:12]([O:13][CH2:14][C:15]([F:18])([F:16])[F:17])=[C:7]([CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:8]=2)=[O:21])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 27358153-Chloro-6-(1-methylhydrazinyl)pyridazineHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 71510018N'-(6-chloropyridazin-3-yl)-5-cyclohexyl-N'-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 12c) and 3-chloro-6-(1-methylhydrazinyl)-pyridazine (CAN 76953-33-8) as starting materials; LC-MS (UV peak area/ESI) 100.0%, 444.1408 (M+H)+.

Sources & evidence

ORD record
ord-c7435d94371f4c3f948f87b282b5308f
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Linked notes

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