N-methyl-N-phenyl-hydrazine → 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid N'-methyl-N'-phenyl-hydrazide

HRID 240731

Reaction equation

HRID 240731 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=[C:8]([CH:12]=2)[C:9]([OH:11])=O)[CH2:3][CH2:2]1.[CH3:19][N:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH2:21]>>[CH3:19][N:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:21][C:9](=[O:11])[C:8]1[CH:12]=[C:4]([CH:1]2[CH2:2][CH2:3]2)[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 36299N-methyl-N-phenyl-hydrazineHCID 712941085-Cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712943655-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid N'-methyl-N'-phenyl-hydrazide

Procedure

The title compound was synthesized in analogy to the procedure described in Example 34 c), using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (example 34b) and N-methyl-N-phenyl-hydrazine (CAN 618-40-6); MS (ESI) 366.2 (M+H)+.

Sources & evidence

ORD record
ord-9db011e11dfb413f88b43d4dfe9e5ff4
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Linked notes

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