tert-butyl N-((4-hydroxypiperidin-4-yl)methyl)carbamate → HCID 70667976, compound
Reaction equation
[OH:1][C:2]1([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]1[S:24][C:25]([CH:28]=O)=[CH:26][N:27]=1>>[OH:1][C:2]1([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH2:7][CH2:6][N:5]([CH2:28][C:25]2[S:24][C:23]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][N:17]=3)=[N:27][CH:26]=2)[CH2:4][CH2:3]1Participants
3
Procedure
According to the same procedure described in Example 101, starting with the compound prepared in Example 251 instead of the compound prepared in Example 226 and the compound prepared in Example 139 instead of 2-phenylthiazole-5-carbaldehyde, the title compound having the following physical data was obtained.
Sources & evidence
- ORD record
- ord-e195638167c14b2090a56ae0314b2b76
- Source dataset
- uspto-grants-2014_08