2-(Pyridin-2-yl)-1,3-thiazole-5-carbaldehyde → HCID 66989601, compound

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][C@@H:17]2[CH2:22][CH2:21][NH:20][CH2:19][C@H:18]2[OH:23])=[O:14])[CH:3]=1.[N:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]1[S:31][C:32]([CH:35]=O)=[CH:33][N:34]=1>>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][C@@H:17]2[CH2:22][CH2:21][N:20]([CH2:35][C:32]3[S:31][C:30]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][N:24]=4)=[N:34][CH:33]=3)[CH2:19][C@H:18]2[OH:23])=[O:14])[CH:3]=1

Participants

Reactant 2

HCID 534037722-(Pyridin-2-yl)-1,3-thiazole-5-carbaldehyde

HCID 66990398HCID 66990398, compound

Product 1

HCID 66989601HCID 66989601, compound

Procedure

According to the same procedure described in Example 101, starting with the compound prepared in Example 268 and the compound prepared in Example 139, the title compound having the following physical data was obtained.

Sources & evidence

ORD record: ord-59b674022f794c57aa84c84f44f07086
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08809538B2

Reaction notes

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