1,4-Dioxane hydrochloride → HCID 67386428, compound
Reaction equation
[CH2:1]([N:8]1[CH2:23][CH2:22][C:11]2([CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24].O1CCOCC1>CO>[ClH:24].[ClH:24].[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]2([CH2:14][NH:13][CH2:12]2)[CH2:22][CH2:23]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of tert-butyl 7-benzyl-2,7-diazaspiro[3.5]nonane-2-carboxylate (CAS 929301-99-5 WO2007030061) in methanol was added 4 N HCl/dioxane. The mixture was stirred at room temperature for 2 hours. The reaction mixture was then concentrated to obtain the title compound. MS (DCI+) m/z 217 (M+H)+.
Workup
- concentrationThe reaction mixture was then concentrated
Sources & evidence
- ORD record
- ord-0931c84e8efb420395ec0559a98c4c80
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08815869B2
Reaction notes
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