HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloro-5-methylpyrimidine → 4-Chloro-5-methyl-6-(phenylmethyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloro-5-methylpyrimidine | HCID 818860 | — |
| Reactant | HCID 178419772 | HCID 178419772 | — |
| Product | 4-Chloro-5-methyl-6-(phenylmethyl)pyrimidine | HCID 86647810 | — |
Reaction Steps
Prepared from 4,6-dichloro-5-methylpyrimidine and benzyl zinc bromide (0.5 M solution in tetrahydrofuran) according to the procedure described in WO 2007/146824 as a colorless oil. 1H NMR (400 MHz, CDCl3): 8.78 (s, 1H), 7.33-7.18 (m, 5H), 4.19 (s, 2H), 2.36 (s, 3H); MS (EI) for C12H11ClN2: 219 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648066B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-99aad49d6c514068be450f3affc03e1c |
| Source note | uspto-grants-2014_02 |