P-Anisidine → 6-chloro-N-(4-methoxyphenyl)-5-methylpyrimidin-4-amine
Reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4](O)[C:3]=1[CH3:9].[CH3:10][O:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:16][C:15]2[CH:17]=[CH:18][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[C:3]=1[CH3:9]Participants
3
Procedure
Synthesized according to the method of reagent preparation 49 using 6-chloro-5-methylpyrimidin-4-ol and 4-methoxyaniline in step 1.
Workup
- customSynthesized
Sources & evidence
- ORD record
- ord-e82967e8b3664001b671f82ae22bb0fd
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648066B2
Reaction notes
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