3-Chloropropanesulphonyl chloride → Methyl 4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoate

Reaction equation

[NH2:1][C:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].Cl[CH2:16][CH2:17][CH2:18][S:19](Cl)(=[O:21])=[O:20]>>[O:20]=[S:19]1(=[O:21])[CH2:18][CH2:17][CH2:16][N:1]1[C:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 154103-Chloropropanesulphonyl chloride

HCID 57572309Methyl 4-(2-aminopropan-2-yl)benzoate

Product 1

HCID 71252862Methyl 4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoate

Procedure

Using methyl 4-(1-amino-1-methylethyl)benzoate (570 mg) and 3-chloropropane-1-sulfonyl chloride (0.47 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (862 mg) was obtained.

Workup

customby the reaction and treatment in the same manner
customas in Preparation Example 17

Sources & evidence

ORD record: ord-56068c774a014b379e91b2179bd9beef
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

Loading…