Methanesulfonyl chloride → methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

Reaction equation

[NH2:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3].[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([NH:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3])(=[O:17])=[O:16]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 17751895Methyl 4-((1S)-1-aminoethyl)benzoate

Product 1

HCID 71262918methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

Procedure

Using methyl (S)-4-(1-aminoethyl)benzoate (0.61 g) and methanesulfonyl chloride (0.29 mL) and by the reaction and treatment in the same manner as in Preparation Example 71, the title compound (0.81 g) was obtained.

Workup

customby the reaction and treatment in the same manner
customas in Preparation Example 71

Sources & evidence

ORD record: ord-fb924fb53f7e423d92e701fbc088fc69
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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