6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone

HRID 2411330

Reaction equation

HRID 2411330 reaction equation
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1.[Br:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][N:17]=1>>[Br:15][C:16]1[N:17]=[CH:18][C:19]([C:20]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][C:4]3[CH:3]=[CH:2][C:1]([CH3:14])=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)=[O:21])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 2389326-Bromonicotinic acidHCID 38374974-(4-Methylphenoxy)piperidine

Product 1

HCID 58484591(6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanoneYield 99.9%

Procedure

Using 4-(p-tolyloxy)piperidine (765 mg) and 6-bromonicotinic acid (808 mg) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.5 g) was obtained.

Workup

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 118

Sources & evidence

ORD record
ord-e46681dc325d47bfaf2d19e9ad6d59c7
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Linked notes

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