4-Methyloxybenzyl chloride → 5-Isopropyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione

Reaction equation

[CH:1]([CH:4]1[NH:8][C:7](=[O:9])[NH:6][C:5]1=[O:10])([CH3:3])[CH3:2].[CH3:11][O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Cl)=[CH:15][CH:14]=1>>[CH:1]([CH:4]1[NH:8][C:7](=[O:9])[N:6]([CH2:17][C:16]2[CH:19]=[CH:20][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)[C:5]1=[O:10])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 699934-Methyloxybenzyl chloride

HCID 1030335-Isopropylhydantoin

Product 1

HCID 712528645-Isopropyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione

Procedure

Using 5-isopropylimidazolidine-2,4-dione (2.00 g) and 4-methoxybenzyl chloride (2.29 mL) and by the reaction and treatment in the same manner as in Preparation Example 51, the title compound (2.72 g) was obtained.

Workup

customby the reaction and treatment in the same manner
customas in Preparation Example 51

Sources & evidence

ORD record: ord-189474c7e3ac4500bdba415a95c91613
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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