2,4-Dibromobenzoic acid → (2,4-Dibromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone
Reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:23]1[CH2:24][CH2:25][N:20]([C:14]2[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=2)[CH2:21][CH2:22]1)=[O:6]Participants
3
Procedure
Using 2,4-dibromobenzoic acid (500 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (343 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (691 mg) was obtained.
Workup
- customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118