1-(2,4,6-Trimethylphenyl)piperazine → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(2,4,6-trimethylphenyl)piperazin-1-yl]methanone

HRID 2411482

Reaction equation

HRID 2411482 reaction equation
[O:1]=[S:2]1(=[O:16])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[C:20]([CH3:25])[C:19]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[O:16]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([N:29]2[CH2:30][CH2:31][N:26]([C:19]3[C:20]([CH3:25])=[CH:21][C:22]([CH3:24])=[CH:23][C:18]=3[CH3:17])[CH2:27][CH2:28]2)=[O:13])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 27608221-(2,4,6-Trimethylphenyl)piperazineHCID 662501152962-52-4

Product 1

HCID 71252840[4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(2,4,6-trimethylphenyl)piperazin-1-yl]methanoneYield 23%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (253 mg) described in Preparation Example 16 and 1-(2,4,6-trimethylphenyl)piperazine (215 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (103 mg) was obtained.

Sources & evidence

ORD record
ord-af5131c153af494fa7170d61c24f4651
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Linked notes

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